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2,3,5-Trifluoro-6-nitroaniline → 3,4,6-Trifluorobenzene-1,2-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3,5-Trifluoro-6-nitroaniline | HCID 223085 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3,4,6-Trifluorobenzene-1,2-diamine | HCID 595624 | 87% |
反応手順
A mixture of 2,3,5-trifluoro-6-nitroaniline (300 mg, 1.56 mmol) and 10% palladium on carbon in absolute ethanol was hydrogenated overnight at atmospheric pressure, filtered under nitrogen and concentrated to provide 1,2-diamino-3,4,6-trifluorobenzene (219 mg, 87% yield) as a purple crystalline solid; MS M+ 162.7, +41. +82 (+ACN, +2ACN). (calcd for C6H5F3N2: 162.11).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06562854B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-5495ef3acb214113a133c8fbd43a5744 |
| 出典メモ | uspto-grants-2003_05 |