2-Amino-6-methylpyrimidin-4-one → Pteroic Acid

HRID 412745

反応式

HRID 412745 の反応式
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.NC1NC(=O)C=C(C)N=1.NC1N=C(C)NC(=O)C=1.N[C:29]1N[C:31](=O)[C:32]2[N:33]=C(S)N[C:36]=2[N:37]=1.NC1SC2C(=O)NC(N)=NC=2N=1.NC1NC(=O)C2C(CNC3[CH:72]=[CH:71][C:67]([C:68]([OH:70])=[O:69])=[CH:66][CH:65]=3)=CNC=2N=1.NC1NC(=O)C2C(CNC3C=CC(CC4C=CC(N)=CC=4)=CC=3)=CNC=2N=1.NC1NC(=O)C2C=C(C)NC=2N=1>>[C:68]([OH:70])(=[O:69])[C:67]1[CH:71]=[CH:72][C:29]([NH:37][CH2:36][C:32]2[N:33]=[C:5]3[C:4]([N:3]=[C:2]([NH:7][C:6]3=[O:8])[NH2:1])=[N:9][CH:31]=2)=[CH:65][CH:66]=1

参加物

9

反応物 8

HCID 1354020552-Amino-6-methylpyrimidin-4-oneHCID 1354087632-AminoisocytosineHCID 1354313302-Methyl-4-amino-6-hydroxypyrimidineHCID 1354538102-Amino-6-methyl-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one2 回HCID 1355153914-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoic acidHCID 1355544462,5-Diaminothiazolo(4,5-d)pyrimidin-7-(6H)-oneHCID 1360508672-Amino-5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-oneHCID 1785082582-amino-8-sulfanyl-3,7-dihydropurin-6-one

生成物 1

HCID 135398749Pteroic Acid

実験手順

The Artemia salinas ribosome in vitro protein synthesis assay was used to analyze the effects of 2,6-diamino-3H-pyrimidin-4-one 1, 2-amino-6-dihydroxy-5-methylpyrimidin-4-one 25, 2-amino-6-methylpyrimidin-4-one 26, 6-amino-2-methyl-3H-pyrimidin-4-one 27, 2-amino-8-mercapto-1,9-dihydro-purin-6-one 28, 2,5-diamino-6H-thiazolo[4,5-d]pyrimidin-7-one 14, 4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoic acid 21, 2-amino-5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 24, and 2-amino-6-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 6 on ricin activity. The results are presented in FIG. 23. 2-amino-6-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 6 was the most effective inhibitor with an IC50 of 0.25 mM.

後処理

  1. customThe Artemia salinas ribosome in vitro protein synthesis assay

出典と根拠

ORDレコード
ord-a4866d61dbf64e61af1a61054a53d068
出典データセット
uspto-grants-2003_05
特許番号
US06562969B1

関連ノート

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