Dibutylamine → N,N-dibutyl-4-tert-butylaniline

HRID 412761

反応式

HRID 412761 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1Br)([CH3:4])([CH3:3])[CH3:2].[CH2:12]([NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH2:13][CH2:14][CH3:15].CC(C)([O-])C.[Na+]>>[CH2:12]([N:16]([CH2:17][CH2:18][CH2:19][CH3:20])[C:8]1[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][CH:7]=1)[CH2:13][CH2:14][CH3:15]

参加物

4

反応物 3

HCID 8148DibutylamineHCID 119590501-Bromo-2-tert-butylbenzeneHCID 23676156Sodium t-butoxide

生成物 1

HCID 10587516N,N-dibutyl-4-tert-butylaniline収率 89.1%

実験手順

According to the general procedure B, 2-tert-butylbromobenzene (213 mg, 1.00 mmol) reacted with N,N-di-n-butylamine (130 mg, 1.00 mmol) using 1 mol % of catalyst and sodium tert-butoxide (115 mg, 1.20 mmol) at 60° C. to give the title compound (233 mg, 89%) as an oil: 1H-NMR (300 MHz, CDCl3): δ 7.25 (d, 2H, J=8.7 Hz), 6.62 (d, 2H, J=8.7 Hz), 3.25 (t, 4H, J=7.2 and 8.1 Hz), 1.58 (m, 4H), 1.35 (M, 4H), 1.30 (s, 9H), 0.97 (t, 6H, J=7.2 Hz). 13C{1H}-NMR (100 MHz, CDCl3): δ 146.01, 137.59, 125.92, 111.29, 50.84, 33.61, 31.56, 29.53, 20.39, 14.02. GC/MS(EI): m/z 261 (M+).

後処理

  1. customat 60° C.

出典と根拠

ORDレコード
ord-72254434698743538a4a9b59a48f87b4
出典データセット
uspto-grants-2003_05
特許番号
US06562989B2

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