Dimethylmaleic anhydride → 2,3-Dimethyl-N-(1-aminocarbonyl-1,2-dimethyl-propyl)maleic acid monoamide

HRID 4128

反応式

HRID 4128 の反応式
[CH3:1][C:2]1=[C:3]([CH3:9])[C:4]([O:6][C:7]1=[O:8])=[O:5].[NH2:10][C:11]([CH3:18])([CH:15]([CH3:17])[CH3:16])[C:12]([NH2:14])=[O:13]>C(Cl)Cl>[CH3:9]/[C:3](=[C:2](\[CH3:1])/[C:7]([OH:6])=[O:8])/[C:4]([NH:10][C:11]([C:12]([NH2:14])=[O:13])([CH3:18])[CH:15]([CH3:17])[CH3:16])=[O:5]

参加物

4

反応物 2

HCID 13010Dimethylmaleic anhydrideHCID 97937732-Amino-2,3-dimethylbutanamide

生成物 1

HCID 138831692,3-Dimethyl-N-(1-aminocarbonyl-1,2-dimethyl-propyl)maleic acid monoamide収率 96.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 46 g of dimethylmaleic acid anhydride, 48 g of 2-amino-2,3-dimethylbutyric acid amide and 70 ml of methylene chloride was heated at its boiling point for 15 minutes. After some of the solvent had been distilled off, the residual mixture was stirred with 300 ml of diethyl ether, and the product precipitated thereby was suction-filtered off. The desired compound (II) (90 g; 96%) was isolated as a crystalline solid, melting point 70°-72° C.

後処理

  1. temperaturewas heated at its boiling point for 15 minutes
  2. distillationAfter some of the solvent had been distilled off
  3. customthe product precipitated
  4. filtrationthereby was suction-filtered off

出典と根拠

ORDレコード
ord-aa9ed74e9a0d49428bacce5162b0c162
出典データセット
uspto-grants-1988_02
特許番号
US04723989

関連ノート

読み込み中…