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Cesium carbonate → 2,5-Dimethyl-2'-methylbiphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Chloro-p-xylene | HCID 32883 | — |
| 反応物 | 2-Methylphenyl boronic acid | HCID 2733267 | — |
| 溶媒 | 1,2-Dioxane | HCID 138570 | — |
| 生成物 | 2,5-Dimethyl-2'-methylbiphenyl | HCID 11816431 | 80.2% |
反応手順
2-Chloro-p-xylene (56 mg, 0.40 mmol) reacted with 2-methylphenylboronic acid (82 mg, 0.60 mmol) using 2.5/5.0 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and Cs2CO3 (391 mg, 1.20 mmol) in 1,2-dioxane at 100° C. to give the title compound (63 mg, 80%): 1H-NMR (300 MHz, CDCl3): δ 7.12-7.18 (m, 6H), 6.97 (s, 1H), 2.37 (s, 3H), 2.10 (s, 3H), 2.05 (s, 3H). 13C{1H}-NMR (125 MHz, CDCl3): δ 141.74, 141.45, 135.77, 134.86, 132.60, 129.94, 129.72, 129.65, 129.26, 127.81, 127.02, 125.47, 20.92, 19.81, 19.28. GC/MS(EI): m/z 196 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06562989B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-e34f34c442a9459ea7db04d1d810b232 |
| 出典メモ | uspto-grants-2003_05 |