2-Bromotoluene → 2,2'-Dimethylbiphenyl

関与物質

役割	名称	HCID	仕込み量
反応物	2-Bromotoluene	HCID 7236	—
反応物	Potassium Fluoride	HCID 522689	—
反応物	2-Methylphenyl boronic acid	HCID 2733267	—
溶媒	Tetrahydrofuran	HCID 8028	—
生成物	2,2'-Dimethylbiphenyl	HCID 11797	98%

反応手順

2-Bromotoluene (87 mg, 0.51 mmol) reacted with 2-methylphenylboronic acid (88 mg, 0.65 mmol) using 1 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and KF (87 mg, 1.50 mmol) in THF solvent at room temperature to give the title compound (91 mg, 98%) as a colorless oil: 1H-NMR (300 MHz, CDCl3): δ 7.29-7.35 (m, 6H), 7.20 (d, 2H, J=6.3 Hz), 2.15 (s, 6H).). 13C{1H}-NMR (100 MHz, CDCl3): δ 141.56, 135.76, 129.77, 129.25, 127.12, 125.51, 19.81. GC/MS(EI): m/z 182 (M+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06562989B2
出典データセット	uspto-grants-2003_05
ORD ID	ord-40b553aec2194ce18bed40f417ad18bc
出典メモ	uspto-grants-2003_05