化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Phosphate, Tribasic → 2,6,2'-Trimethyl-biphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | 2-Bromo-m-xylene | HCID 68471 | — |
| 反応物 | 2-Methylphenyl boronic acid | HCID 2733267 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2,6,2'-Trimethyl-biphenyl | HCID 9813037 | 87% |
反応手順
2-Bromo-m-xylene (186 mg, 1.01 mmol) reacted with 2-methylphenylboronic acid (164 mg, 1.21 mmol) using 2/4 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and K3PO4 (640 mg, 3.00 mmol) in toluene at 100° C. to give the title compound (170 mg, 87%) as a colorless oil: 1H-NMR (400 MHz, CDCl3): δ 7.31-7.25 (m, 3H), 7.20-7.11 (m, 3H), 7.03 (m, 1H), 1.98 (s, 3H), 1.96 (s, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06562989B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-0ff99723968a4418be2450efd7a59780 |
| 出典メモ | uspto-grants-2003_05 |