Water → 1-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-4-iodobenzene
反応式
[C:1]([Si:5](Cl)([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2].[I:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1.O>CN(C)C=O>[I:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][Si:5]([CH3:7])([CH3:6])[C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:12][CH:11]=1参加物
5
実験手順
387 mg of irdidazole and 411 mg of tertbutyldimethylsilyl chloride is added at ambient temperature and under an inert atmosphere to 500 mg of para-iodo-phenol in 4 ml of dimethylformamide and the mixture is maintained under agitation for 15 hours at ambient temperature then for 1 hour at 40° C. The reaction medium is poured into water, and the aqueous phase is extracted with dichloromethane. The organic phase is then dried and evaporated under reduced pressure. In this way 636 mg of expected product is obtained.
後処理
- extractionthe aqueous phase is extracted with dichloromethane
- customThe organic phase is then dried
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-3717608e307444c5b74b81a0bbac5090
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06563008B2
反応ノート
読み込み中…