2-Bromo-1-(3,4-dimethoxyphenyl)ethan-1-one → Methyl 4-[4-(3,4-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiophene-2-carboxylate

HRID 412968

反応式

HRID 412968 の反応式
[NH2:1][C:2](=[S:13])[C:3]1[CH:4]=[C:5]([C:9]([O:11][CH3:12])=[O:10])[S:6][C:7]=1[CH3:8].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:24](=O)[CH2:25]Br)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]>>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:24]2[N:1]=[C:2]([C:3]3[CH:4]=[C:5]([C:9]([O:11][CH3:12])=[O:10])[S:6][C:7]=3[CH3:8])[S:13][CH:25]=2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

参加物

3

反応物 2

HCID 2704232-Bromo-1-(3,4-dimethoxyphenyl)ethan-1-oneHCID 18537096Methyl 4-(aminothioxomethyl)-5-methylthiophene-2-carboxylate

生成物 1

HCID 18536810Methyl 4-[4-(3,4-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiophene-2-carboxylate収率 53%

実験手順

Methyl 4-[4-(3,4-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-metltylthiophene-2-carboxylate: A solution of 257 mg (0.48 mmol, based on a mixture containing 60% nitrile) of methyl 4-(aminothioxomethyl)-5-methylthiophene-2-carboxylate was reacted with 124 mg (0.48 nmuol) of 2-bromo-(3′, 4′-dimethoxy)-acetophenone (Example 31, step (a)) was reacted in a manner similar to Example 8, step (a) to give methyl 4-[4-(3,4-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiophene-2-carboxylate (95 mg, 53%) as a solid. Mass spectrum (MALDI-TOF, CHCA matrix, m/z): Calcd. for C18H17NO4S2 376.1 (M+H), found 376.3.

後処理

  1. customwas reacted in a manner similar to Example 8, step (a)

出典と根拠

ORDレコード
ord-49db123dd62343b6ba80738a65a40390
出典データセット
uspto-grants-2003_05
特許番号
US06562840B1

関連ノート

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