化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Benzyl 4-methylidenepyrazolidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Benzyl tert-butyl 4-methylidenepyrazolidine-1,2-dicarboxylate | HCID 12970152 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Benzyl 4-methylidenepyrazolidine-1-carboxylate | HCID 12970153 | 97% |
反応手順
To a solution of crude 4-methylenepyrazolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester, 1, (30 g) in methanol (300 mL) is added thionyl chloride dropwise at 0° C. The reaction is warmed to room temperature and stirred an additional 18 hours. Concentration of the reaction in vacuo affords a yellow oil which crystallizes upon standing to provide 23 g (97% yield) of the desired product as the HCl salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06566357B1 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-af422b1a592b4583b747bf5daf50f0f5 |
| 出典メモ | uspto-grants-2003_05 |