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Ethyl Bromide → 2-Ethoxybenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Bromide | HCID 6332 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Hydroxybenzonitrile | HCID 11907 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-Ethoxybenzonitrile | HCID 576922 | — |
反応手順
25 g (210 mmol) of 2-hydroxybenzonitrile are refluxed with 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide in 500 ml of acetone overnight. The solid is filtered off, the solvent is removed under reduced pressure and the residue is distilled under reduced pressure. This gives 30.0 g (97%) of a colourless liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06566360B1 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-07a43eea951d4b759ece091b7f3e811d |
| 出典メモ | uspto-grants-2003_05 |