Ammonia → 4-Hydroxy-4-phenylbutanamide

HRID 413197ノート

反応式

HRID 413197 の反応式
[C:1]1([CH:7]2[O:12][C:10](=[O:11])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:13]>>[OH:12][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:8][CH2:9][C:10]([NH2:13])=[O:11]

参加物

3

反応物 2

HCID 222AmmoniaHCID 13884gamma-Phenyl-gamma-butyrolactone

生成物 1

HCID 114239224-Hydroxy-4-phenylbutanamide収率 75%

実験手順

A mixture of γ-phenyl-γ-butyrolactone (10.30 g, 63.5 mmol) and an excess of ammonia was stirred under nitrogen and a dry ice trap for 8 hours. The dry ice trap was removed and after evaporation of the ammonia 11.27 g of a tan solid remained. Recrystallization of the solid from ethyl acetate-hexane gave 4-hydroxy-4-phenyl-butyramide (8.56 g, 75%) as a white solid, mp 85-87° C.

後処理

  1. customThe dry ice trap was removed
  2. customafter evaporation of the ammonia 11.27 g of a tan solid
  3. customRecrystallization of the solid from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-3eaebed73b704a16862613d59c621803
出典データセット
uspto-grants-2003_05
特許番号
US06566375B1

反応ノート

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