Benzylamine → n-Benzyl-4-hydroxy-4-phenylbutanamide

HRID 413199

反応式

HRID 413199 の反応式
[C:1]1([CH:7]2[O:12][C:10](=[O:11])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1C=CC=CC=1>[CH2:13]([NH:20][C:10](=[O:11])[CH2:9][CH2:8][CH:7]([OH:12])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 7504Benzylamine2 回HCID 13884gamma-Phenyl-gamma-butyrolactone

生成物 1

HCID 288829n-Benzyl-4-hydroxy-4-phenylbutanamide収率 72%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A solution of γ-phenyl-γ-butyrolactone (5.17 g, 31.8 mmol) and benzylamine (3.48 ml, 31.8 mmol) in 200 ml of benzene was refluxed under a nitrogen atmosphere for 20 hours. An additional 1.75 ml (16.0 mmol) of benzylamine was added and the solution refluxed for 24 hours. When the reaction was partitioned with 1 N HCl a white solid precipitated. The solid was collected by filtration and dried to give N-benzyl-4-hydroxy-4-phenyl-butyramide (6.12 g, 72%) as a white solid, mp 92-94° C.

後処理

  1. temperaturethe solution refluxed for 24 hours
  2. customWhen the reaction was partitioned with 1 N HCl a white solid
  3. customprecipitated
  4. filtrationThe solid was collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-e9144b19985e48ea88b9eec6e67e60ca
出典データセット
uspto-grants-2003_05
特許番号
US06566375B1

関連ノート

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