Water → 1,1'-(1-Bromoethane-1,2-diyl)dibenzene

HRID 41321

反応式

HRID 41321 の反応式
[C:1]1([CH:7](O)[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Br)(Br)[Br:17].O>C(OCC)C>[Br:17][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 941781,2-Diphenylethanol

生成物 1

HCID 124997111,1'-(1-Bromoethane-1,2-diyl)dibenzene収率 84%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
-10 °C

実験手順

To a solution of 12.0 (60.5 mmol) of 1,2-diphenylethanol in 50 mL of dry diethyl ether, 11.0 g (3.80 mL, 40.0 mmol) of PBr3 was added with vigorous stirring at −10° C. The resulting mixture was stirred for 12 hr at room temperature and then added to 350 mL of cold water. The organic layer was separated, and the aqueous layer was extracted with 2×100 mL of water. The combined organic extracts were washed with aqueous NaHCO3, dried over Na2SO4, and evaporated to dryness. This procedure gave 13.2 g (84%) of the title product.

後処理

  1. stirringThe resulting mixture was stirred for 12 hr at room temperature
  2. customThe organic layer was separated
  3. extractionthe aqueous layer was extracted with 2×100 mL of water
  4. washThe combined organic extracts were washed with aqueous NaHCO3
  5. dry with materialdried over Na2SO4
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-955a6e2a0d374c7495f12d087392dfcb
出典データセット
uspto-grants-2013_09
特許番号
US08530593B2

関連ノート

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