Benzaldehyde → HCID 178489586、化合物

HRID 41326ノート

反応式

HRID 41326 の反応式
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=1[NH2:13]>C1(C)C=CC=CC=1>[CH3:9][O:10][C:11]1[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=1/[N:13]=[CH:1]/[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 240BenzaldehydeHCID 70002-Methoxyaniline

生成物 1

HCID 178489586HCID 178489586、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 31.8 g (0.30 mol) of benzaldehyde, 36.9 g (0.30 g) of 2-methoxyaniline and 450 mL of toluene was refluxed using a Dean-Stark head for 1 hr. 15 granules of 4A molecular sieves were added. This mixture was refluxed for 4 hr, then filtered off, and the filtrate was evaporated to dryness. The residue was dried in vacuum at 70° C. This crude product was further used without an additional purification, since it is unstable on silica gel 60 and decomposes when dried under vacuum. Yield 52.0 g (82%) of the title material.

後処理

  1. temperaturewas refluxed
  2. customfor 1 hr
  3. temperatureThis mixture was refluxed for 4 hr
  4. filtrationfiltered off
  5. customthe filtrate was evaporated to dryness
  6. customThe residue was dried in vacuum at 70° C
  7. customThis crude product was further used without an additional purification, since it
  8. customdried under vacuum

出典と根拠

ORDレコード
ord-c8f4ee2ab0a142a4b1a7590925e67ed8
出典データセット
uspto-grants-2013_09
特許番号
US08530593B2

反応ノート

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