Benzyl Bromide → 1-benzyl-1H-pyrazole-3-carbaldehyde
反応式
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[CH:12][C:11]([CH:14]=[O:15])=[N:10]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:1]([N:9]1[CH:13]=[CH:12][C:11]([CH:14]=[O:15])=[N:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of benzyl bromide (0.29 g) in N,N-dimethylformamide (9 ml) was added 1H-pyrazole-3-carboxaldehyde (0.15 g) and potassium carbonate (0.24 g). The mixture was stirred at room temperature for 24 hours, silica gel was added, the solvent removed by evaporation and the crude material purified by chromatography (isohexane:ether, 2:1) to give the product as an oil (0.18 g).
後処理
- additionsilica gel was added
- customthe solvent removed by evaporation
- customthe crude material purified by chromatography (isohexane:ether, 2:1)
出典と根拠
- ORDレコード
- ord-6d33378c29d04b489b7fbd4671e4aa97
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06566376B1
反応ノート
読み込み中…