Thiobenzamide → N-[2-[4-(2-Phenyl-thiazol-4-yl)-phenyl]-ethyl}-acetamide

HRID 413294

反応式

HRID 413294 の反応式
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=[O:25])[CH3:24])=[CH:16][CH:15]=1)=O>C(O)C>[C:2]1([C:1]2[S:8][CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=[O:25])[CH3:24])=[CH:16][CH:15]=3)[N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 683563ThiobenzamideHCID 18523617N-[2-(4-Bromoacetyl-phenyl)-ethyl]-acetamide

生成物 1

HCID 9343045N-[2-[4-(2-Phenyl-thiazol-4-yl)-phenyl]-ethyl}-acetamide収率 100%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

In a round-bottomed flask, thiobenzamide (357 mg, 2.60 mmol) and N-[2-(4-bromoacetyl-phenyl)-ethyl]-acetamide (740 mg, 2.60 mmol) were combined in ethanol (30 ml) and heated to about 80° C. for about three hours. The reaction mixture was then concentrated in vacuo to yield an off-white solid. The resulting material (838 mg, 100% yield) was ascertained to be pure by NMR and was carried into the next step directly without further purification. LRMS ([M+H]+)=323.2.

後処理

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto yield an off-white solid

出典と根拠

ORDレコード
ord-81e17ae6d069429eace8613d4739982c
出典データセット
uspto-grants-2003_05
特許番号
US06566377B2

関連ノート

読み込み中…