関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitromethane | HCID 6375 | — |
| 反応物 | 2,6-Di-tert-butylpyridine | HCID 68510 | — |
| 反応物 | 3-Bromopropyl 1,1,1-trifluoromethanesulfonate | HCID 124865 | — |
| 反応物 | (4-Methoxycyclohexyl)methanol | HCID 18533153 | — |
| 生成物 | 1-[4-(3-Bromo-propoxymethyl)-cyclohexyl]-4-methoxybenzene | HCID 18533007 | 61% |
反応手順
To a mixture of (4-methoxy-cyclohexyl)-methanol (1.25 g, 8.7 mmol) and trifluoromethanesulfonic acid 3-bromo-propyl ester (2.58 g, 9.55 mmol) in nitromethane (15 ml) was added 2,6-di-tert-butylpyridine (1.83 ml, 9.55 mmol). The reaction mixture was heated at 80° C. for 18 hours. The mixture was concentrated in vacuo and the residue purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane to give the title compound as a yellow oil (1.4 g, 61%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06566384B1 |
|---|
| 出典データセット | uspto-grants-2003_05 |
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| ORD ID | ord-957ee6ca47354056ba5f062aa3928ef5 |
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| 出典メモ | uspto-grants-2003_05 |
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