Potassium Hydroxide → 5-[1-(3-Methoxy-phenyl)-2-oxo-cyclohexyl]-pentanoic acid

HRID 413426

反応式

HRID 413426 の反応式
[OH-].[K+].C([O:5][C:6](=[O:26])[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[CH2:16][CH2:15][CH2:14][CH2:13][C:12]1=[O:17])C>CCO>[CH3:25][O:24][C:20]1[CH:19]=[C:18]([C:11]2([CH2:10][CH2:9][CH2:8][CH2:7][C:6]([OH:26])=[O:5])[CH2:16][CH2:15][CH2:14][CH2:13][C:12]2=[O:17])[CH:23]=[CH:22][CH:21]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 700297965-[1-(3-Methoxy-phenyl)-2-oxo-cyclohexyl]-pentanoic acid ethyl ester

生成物 1

HCID 185331945-[1-(3-Methoxy-phenyl)-2-oxo-cyclohexyl]-pentanoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Solid KOH (0.090 g, 1.4 mmol) was added to a solution of the ester from Step A (0.132 g, 0.38 mmol) in EtOH (5 mL). After stirring at ambient temperature for 48 hr, the reaction mixture was partitioned between EtOAc (50 mL) and H2O (100 mL), the aqueous layer acidified, then extracted with EtOAc (2×100 mL), the organic layer washed with H2O (50 mL), dried (Na2SO4), filtered, and concentrated to dryness to give the title compound. Mp 89-91° C. MS 318.

後処理

  1. customthe reaction mixture was partitioned between EtOAc (50 mL) and H2O (100 mL)
  2. extractionextracted with EtOAc (2×100 mL)
  3. washthe organic layer washed with H2O (50 mL)
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-1b6bfe12da7f4683afa11fcac00accc3
出典データセット
uspto-grants-2003_05
特許番号
US06566385B2

関連ノート

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