化工社化工社 化学情報印刷レポート · 研究参考用
Phosgene → 10-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | Oxcarbazepine | HCID 34312 | — |
| 反応物 | 10-Methoxyiminostilbene | HCID 78424 | — |
| 生成物 | 10-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride | HCID 16050081 | — |
反応手順
U.S. Pat. No. 3,642,775 assigned to Ciba-Geigy Corporation, claims Oxcarbazepine specifically and discloses the process for the preparation of Oxcarbazepine, wherein 10-methoxy-5H-dibenz[b,f]azepine is reacted with phosgene gas to give 10-methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride and ammonolysis of the resultant compound to give the amide followed by hydrolysis to give Oxcarbazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530647B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-60bf5f9e5dc041ce8cc30181f4c613f9 |
| 出典メモ | uspto-grants-2013_09 |