化工社化工社 化学情報印刷レポート · 研究参考用
Mandelic Acid → 10-methoxy-5H-dibenz(b,f)azepine-5-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Mandelic Acid | HCID 1292 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 10-Methoxyiminostilbene | HCID 78424 | — |
| 反応物 | Sodium Cyanate | HCID 517096 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 10-methoxy-5H-dibenz(b,f)azepine-5-carboxamide | HCID 120031 | 83.8% |
反応手順
A suspension of 10 g of 10-methoxyiminostilbene in 200 ml toluene was treated with 20 g of sodium cyanate and 39 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 19 hrs. The resulting suspension was filtered, washed with water and dried to give 10 g of 10-methoxy carbamazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530647B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-d481f292f5d5474a8f07a889c5a31c7f |
| 出典メモ | uspto-grants-2013_09 |