化工社化工社 化学情報印刷レポート · 研究参考用
Mandelic Acid → Carbamazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Mandelic Acid | HCID 1292 | — |
| 反応物 | Dibenz(b,f)azepine | HCID 9212 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium Cyanate | HCID 517096 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Carbamazepine | HCID 2554 | 90% |
反応手順
A suspension of 10 g of iminostilbene in 100 ml toluene was treated with 20.2 g of sodium cyanate and 27.5 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 8 hrs. The resulting suspension was filtered, washed with water and dried to give 11 g of carbamazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530647B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-9156a4b6f0a14fffb3d533decc5b9669 |
| 出典メモ | uspto-grants-2013_09 |