Hydrochloric Acid → 2-Methyl-4-aminobiphenyl hydrochloride

HRID 413497ノート

反応式

HRID 413497 の反応式
O.[ClH:2].[CH3:3][C:4]1[CH:9]=[C:8]([NH:10]C(C)=O)[CH:7]=[CH:6][C:5]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)(=O)C>[ClH:2].[CH3:3][C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:5]=1[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 111721562-Methyl-4-acetaminobiphenyl

生成物 1

HCID 185334912-Methyl-4-aminobiphenyl hydrochloride

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

300 g of water and 296 g of HCl (37%) are added to the 2-methyl-4-acetaminobiphenyl prepared as described in Example 1. Any chlorobenzene still present is distilled off azeotropically, and the mixture is subsequently refluxed until HPLC monitoring indicates complete conversion (about 4 hours). The suspension obtained can be reacted further without further purification and without removal of the acetic acid formed as coproduct in the cleavage. The yield is (calculated from HPLC percentages by area) 99%.

後処理

  1. customprepared
  2. distillationAny chlorobenzene still present is distilled off azeotropically
  3. temperaturethe mixture is subsequently refluxed until HPLC monitoring
  4. customconversion (about 4 hours)
  5. customThe suspension obtained can
  6. customformed as coproduct in the cleavage

出典と根拠

ORDレコード
ord-8a894b2f7d324691a6aeecead6b50a5b
出典データセット
uspto-grants-2003_05
特許番号
US06566546B2

反応ノート

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