Methanol → Methyl 2-aminoisobutyrate hydrochloride

関与物質

反応手順

To a suspension of 2-aminoisobutyric acid (25.0 g, 243 mmol) in methanol (300 mL) was added thionyl chloride (27.0 mL, 43.0 g, 365 mmol) and the reaction was heated at reflux for 12 hours. The resulting solution was concentrated and triturated with diethyl ether-tetrahydrofuran to yield the product as a white powder, 29.8 g (80%).

情報源と証拠