Methanol → Methyl 2-aminoisobutyrate hydrochloride

HRID 41355

反応式

HRID 41355 の反応式
[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([O:5][CH3:12])=[O:4]

参加物

4

反応物 3

HCID 887MethanolHCID 6119Aminoisobutyric acidHCID 24386Thionyl Chloride

生成物 1

HCID 13258034Methyl 2-aminoisobutyrate hydrochloride

実験手順

To a suspension of 2-aminoisobutyric acid (25.0 g, 243 mmol) in methanol (300 mL) was added thionyl chloride (27.0 mL, 43.0 g, 365 mmol) and the reaction was heated at reflux for 12 hours. The resulting solution was concentrated and triturated with diethyl ether-tetrahydrofuran to yield the product as a white powder, 29.8 g (80%).

後処理

  1. temperaturethe reaction was heated
  2. temperatureat reflux for 12 hours
  3. concentrationThe resulting solution was concentrated
  4. customtriturated with diethyl ether-tetrahydrofuran

出典と根拠

ORDレコード
ord-dec8121f10da4ad8809931f9538cbab1
出典データセット
uspto-grants-2013_09
特許番号
US08530651B2

関連ノート

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