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Dihydrosafrole → Eugenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dihydrosafrole | HCID 7197 | — |
| 反応物 | Propylbenzene | HCID 7668 | — |
| 反応物 | 4-Propylanisole | HCID 7702 | — |
| 反応物 | 6-Methoxy-4-prop-2-enylcyclohexa-2,4-dien-1-ol | HCID 20975719 | — |
| 生成物 | Eugenol | HCID 3314 | — |
| 生成物 | Safrole | HCID 5144 | — |
| 生成物 | 1-Methoxy-4-Prop-1-Enylbenzene | HCID 7703 | — |
反応手順
The starting material phenylpropane derivatives such as dihydroeugenol (n-Propyl guaiacol), 3,4-Methylenedioxy phenylpropane (dihydrosafrole), 4-Methoxyphenylpropane (dihydroanethole) or the like, can be obtained either from commercial sources or by catalytic hydrogenation of corresponding eugenol, safrole, anethole derivatives respectively (Steffen, A. In: Perfume and Flavor Chemicals, Allured Punlishing Corporation, 362 South Schmale Road, Carol Stream, Ill., USA, (1994)). In addition, 2,4,5-Trimethoxyphenylpropane can be obtained via ammonium formate assisted reduction of toxic β-asarone of Acorus calamus or crude calamus oil containing β-asarone (Sinha, A. K., U.S. Ser. No. 09/652,376 filed on Aug. 31, (2000)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06566557B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-446d15699a9549769ca329e1e669c36f |
| 出典メモ | uspto-grants-2003_05 |