Ethyl 4-sulfanylbutanoate → Ethyl 4-(4-bromo-2-formylphenylthio)butyrate

HRID 413588ノート

反応式

HRID 413588 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[SH:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:6]([CH:7]=[O:8])[CH:9]=1

参加物

3

反応物 2

HCID 271824Ethyl 4-sulfanylbutanoateHCID 7363275-Bromo-2-fluorobenzaldehyde

生成物 1

HCID 18533381Ethyl 4-(4-bromo-2-formylphenylthio)butyrate収率 78%

実験手順

Ethyl 4-(4-bromo-2-formylphenylthio)butyrate was synthesized from 5-bromo-2-fluorobenzaldehyde and ethyl 4-mercaptobutyrate in the same manner as Example 2. After column chromatography, crystallization from hexane/isopropyl ether yielded ethyl 4-(4-bromo-2-formylphenylthio)butyrate (Yield 78%) as yellow crystals.

後処理

  1. customAfter column chromatography, crystallization from hexane/isopropyl ether

出典と根拠

ORDレコード
ord-fc31491f255a44a8bf42c367ec655516
出典データセット
uspto-grants-2003_05
特許番号
US06566535B1

反応ノート

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