Piperidine → Imidazolyl indolinone

HRID 413727

反応式

HRID 413727 の反応式
C([C:3]1[NH:4][CH:5]=[C:6](C=O)[N:7]=1)C.C1C=CC(C(Cl)(C2C(Cl)=CC=CC=2)C2C=CC=CC=2)=CC=1.N1CCCCC1.[NH:37]1[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39][C:38]1=[O:46]>CN(C=O)C>[NH:4]1[CH:5]=[CH:6][N:7]=[C:3]1[N:37]1[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39][C:38]1=[O:46]

参加物

6

反応物 4

HCID 8082PiperidineHCID 945242-Chlorotrityl chlorideHCID 321710OxindoleHCID 178437699HCID 178437699、化合物

生成物 1

HCID 23177814Imidazolyl indolinone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-ethyl-4-formylimidazole attached to 2-chlorotrityl resin (4, 78 mg, 0.052 mmol based on 0.67 mmol/g loading), DMF (0.9 ml) and piperidine (0.1 ml) was gently stirred for 45 min. at ambient temperature, afterwhich was added 2-indolinone (5, 70 mg, 0.523 mmol). The resultant mixture was gently stirred and heated at 80° C. for 20 h. The resin was filtered and washed with 30 ml each of acetone, water, dichloromethane, methanol, and another portion of acetone. Finally, the resin was air dried for 20 min.

後処理

  1. temperatureheated at 80° C. for 20 h
  2. filtrationThe resin was filtered
  3. washwashed with 30 ml each of acetone, water, dichloromethane, methanol
  4. customdried for 20 min.

出典と根拠

ORDレコード
ord-cf0e67eac901434eaae9842178cdff62
出典データセット
uspto-grants-2003_05
特許番号
US06569868B2

関連ノート

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