Acetyl chloride → N-(5-Nitro-1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide

HRID 413879ノート

反応式

HRID 413879 の反応式
[C:1]([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][CH:11]=[C:7]([C:8]([OH:10])=O)[C:6]=1[C:17]([OH:19])=[O:18])(=[O:3])[CH3:2].C(Cl)(=O)C>C(OC(=O)C)(=O)C>[C:1]([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][CH:11]=[C:7]2[C:8]([O:19][C:17](=[O:18])[C:6]=12)=[O:10])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 155118403-Acetamido-4-nitrophthalic acid

生成物 1

HCID 15511835N-(5-Nitro-1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide収率 58%

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

3-Acetamido-4-nitrophthalic acid (0.538 g, 2.00 mmol) was dissolved in acetic anhydride (10 ml) at 80° C., and the solution was added with acetyl chloride (1 ml) and stirred for 2 hours. The solvent was evaporated, and a small amount of anhydrous dichloromethane was added to the residue, and precipitates were collected by filtration to obtain the title compound (0.29 g, 58%).

後処理

  1. customThe solvent was evaporated
  2. additiona small amount of anhydrous dichloromethane was added to the residue
  3. customprecipitates
  4. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-04b2eea8c4d240e382be4d493d52b2a8
出典データセット
uspto-grants-2003_05
特許番号
US06569892B2

反応ノート

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