Homoveratrylamine → SB-237376

HRID 413978

反応式

HRID 413978 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:16])[C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1.[CH2:17]([NH2:29])[CH2:18][C:19]1[CH:28]=[CH:27][C:24]([O:25][CH3:26])=[C:21]([O:22][CH3:23])[CH:20]=1.C(N(CC)CC)C>C(Cl)Cl>[ClH:1].[CH3:23][O:22][C:21]1[CH:20]=[C:19]([CH2:18][CH2:17][NH:29][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:16])[C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)[CH:28]=[CH:27][C:24]=1[O:25][CH3:26]

参加物

5

反応物 3

HCID 8421HomoveratrylamineHCID 8471TriethylamineHCID 3421653N-(3-chloropropyl)-4-nitrobenzamide

生成物 1

HCID 9845213SB-237376収率 23.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 10.62 g (44 mmol) N-(3-chloropropyl)-4nitrobenzamide (D3), 8.1 g (45 mmol) homoveratrylamine and 6.26 ml triethylamine in 200 ml methylene chloride was refluxed for 48h. The solvent was then concentrated in vacuo and the residue dissolved in water. The aqueous phase was first washed with methylene chloride, then made basic with aqueous NaOH and finally extracted twice with methylene chloride. This second organic phase was dried over MgSO4 and concentrated in vacuo affording 12 g of a crude residue. This residue was purified by chromatography on silicagel using CH2Cl2/MeOH/NH4OH: 85/10/5 to afford 4.4 g of the title compound as an yellow oil (free base).

後処理

  1. concentrationThe solvent was then concentrated in vacuo
  2. dissolutionthe residue dissolved in water
  3. washThe aqueous phase was first washed with methylene chloride
  4. extractionfinally extracted twice with methylene chloride
  5. dry with materialThis second organic phase was dried over MgSO4
  6. concentrationconcentrated in vacuo
  7. customaffording 12 g of a crude residue
  8. customThis residue was purified by chromatography on silicagel

出典と根拠

ORDレコード
ord-cd6ee46581ff462da1b24e1d705acd07
出典データセット
uspto-grants-2003_05
特許番号
US06570037B2

関連ノート

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