化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Pyridinecarboxylic acid, 2-[(phenylmethyl)thio]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | HCID 178524460 | HCID 178524460 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Pyridinecarboxylic acid, 2-[(phenylmethyl)thio]- | HCID 757779 | 97.1% |
反応手順
200 parts 2-mercaptonicotinic acid, 970 parts of water, 215 parts of 50% NaOH, and 164 parts of benzyl chloride were combined and the resulting solution was refluxed for 2 hours. After dilution with 2580 parts of water, the solution was acidified with 207 parts of 36% HCl. The resulting slurry was cooled and filtered. The wet cake was washed with water and dried to give 307 parts (97.1%) of 2-(phenylmethylthio)-3-pyridinecarboxylic acid, m.p. 190°-193° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04789393 |
| 出典データセット | uspto-grants-1988_12 |
| ORD ID | ord-efa42f0a24d648f6a6467fcab5f00161 |
| 出典メモ | uspto-grants-1988_12 |