Methyl acetoacetate → HCID 178500546、化合物

HRID 414018

反応式

HRID 414018 の反応式
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[F:9][C:10]([F:14])([F:13])[C:11]#[N:12]>CC(C)([O-])C.[K+]>[C:3]([C:2](=[C:11]([NH2:12])[C:10]([F:14])([F:13])[F:9])[C:1]([O:7][CH3:8])=[O:6])(=[O:4])[CH3:5]

参加物

4

反応物 2

HCID 7757Methyl acetoacetateHCID 67710Trifluoroacetonitrile

生成物 1

HCID 178500546HCID 178500546、化合物収率 66%

試薬・触媒・溶媒 1

HCID 23665647Potassium tert-butoxide触媒

実験手順

To a 1 liter, four-necked flask equipped with nitrogen inlet, thermometer, and mechanical stirrer was charged 499.74 g (490 ml, 3.84 mol) of methyl acetoacetate and 12.9 g (0.115 mol) of potassium t-butoxide. The resulting mixture was stirred while 391 g (4.04 mol) of trifluoroacetonitrile was added. The reaction mixture was washed with hexane and the resulting solid was dried in vacuo affording 535 g (62%) of the enamine as a yellow solid; mp 63°-65° C.

後処理

  1. customTo a 1 liter, four-necked flask equipped with nitrogen inlet
  2. additionwas added
  3. washThe reaction mixture was washed with hexane
  4. customthe resulting solid was dried in vacuo

出典と根拠

ORDレコード
ord-8428274974d4438cab1e0d2f94ed7c81
出典データセット
uspto-grants-1988_12
特許番号
US04789395

関連ノート

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