化工社化工社 化学情報印刷レポート · 研究参考用
Water → 3-(4-Trifluoromethylphenylthio)propanal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Acrolein | HCID 7847 | — |
| 反応物 | 4-(Trifluoromethyl)thiophenol | HCID 136653 | — |
| 触媒 | Triethylamine | HCID 8471 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(4-Trifluoromethylphenylthio)propanal | HCID 14347982 | 99.6% |
反応手順
Ten grams of 4-trifluoromethylthiophenol was dissolved in 15 ml of THF, and after adding 4.0 g of 95% acrolein under ice-cooling, 0.1 g of triethylamine was added while thoroughly stirring the reaction solution. After stirring for 1.5 hours under ice-cooling, the reaction solution was poured into water and extracted with ether. The ether layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to obtain 13.1 g of 3-(4-trifluoromethylphenylthio)propionaldehyde.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04789396 |
| 出典データセット | uspto-grants-1988_12 |
| ORD ID | ord-8fffb9f5120448a293a9012ddff4bfe1 |
| 出典メモ | uspto-grants-1988_12 |