関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 3-Hydroxyphthalic anhydride | HCID 96580 | — |
| 反応物 | 2,4-Dimethoxybenzylamine | HCID 597250 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(2,4-Dimethoxy-benzyl)-4-hydroxy-isoindole-1,3-dione | HCID 59263128 | 73% |
反応手順
A mixture of 3-hydroxyphthalic anhydride (1.24 g, 7.6 mmol), 2,4-dimethoxybenzylamine (1.14 mL, 7.6 mmol) and acetic acid (5 mL) was heated at 80° C. for 24 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (1.73 g, 73%). 1H NMR (DMSO-d6) 11.00 (1H, s), 7.62 (1H, dd), 7.29 (1H, d), 7.21 (1H, d), 6.90 (1H, d), 6.56 (1H, d), 6.43 (1H, dd), 4.59 (2H, s), 3.79 (3H, s), 3.72 (3H, s). MS: [M−H+] 314.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08530469B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-3204a4b7bfac4724a29b02172a4d9b12 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
