Triethylamine → N-methoxycarbonylacetyl-N-methoxycarbonylmethyl-beta-aminopropionic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:12])[CH2:4][CH2:5][NH:6][CH2:7][C:8]([O:10][CH3:11])=[O:9].C(N(CC)CC)C.[Cl-].[CH3:21][O:22][C:23](=[O:28])[CH2:24][C:25](O)=[O:26]>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:12])[CH2:4][CH2:5][N:6]([C:25](=[O:26])[CH2:24][C:23]([O:22][CH3:21])=[O:28])[CH2:7][C:8]([O:10][CH3:11])=[O:9]参加物
5
実験手順
Analogously to the procedure described in Example 1(a), from 35.0 g (0.2 mol) of N-(methoxycarbonylmethyl)-β-aminopropionic acid methyl ester, 33 ml (0.24 mol) of triethylamine and 36.2 g (0.24 mol) of malonic acid monomethyl ester chloride in 60 ml of methylene chloride there is obtained N-methoxycarbonylacetyl-N-methoxycarbonylmethyl-β-aminopropionic acid methyl ester in the form of a yellowish oil.