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Potassium Carbonate → 6-[(4"-Aminobenzoyl)azo]-8-{[(aminocarbonyl)oxy]methyl}-4,7-dihydroxy-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-azirino[2',3':3,4]pyrrolo[1,2-a)indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Mitomycin A | HCID 19972 | — |
| 反応物 | 4-Aminobenzoic acid hydrazide | HCID 21450 | — |
| 生成物 | 6-[(4"-Aminobenzoyl)azo]-8-{[(aminocarbonyl)oxy]methyl}-4,7-dihydroxy-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-azirino[2',3':3,4]pyrrolo[1,2-a)indole | HCID 136342835 | 40.5% |
反応手順
In a similar manner to that described in Example 17, mitomycin A (302 mg), 4-aminobenzoylhydrazine (389 mg) and potassium carbonate (150 mg) are used to obtain the desired product (163 mg) with a yield of 40.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04791113 |
| 出典データセット | uspto-grants-1988_12 |
| ORD ID | ord-f43c1da2a11c473abcc24aaa81d56c1c |
| 出典メモ | uspto-grants-1988_12 |