Olprinone → 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 414314

反応式

HRID 414314 の反応式
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[C:5]([C:9]#[N:10])=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[CH:18][N:19]=2)[CH:16]=1.[OH2:20].N>S(=O)(=O)(O)O>[CH3:1][C:2]1[NH:7][C:6](=[O:8])[C:5]([C:9]([NH2:10])=[O:20])=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[CH:18][N:19]=2)[CH:16]=1

参加物

4

反応物 2

HCID 4593OlprinoneHCID 12896473Azane;hydrate

生成物 1

HCID 138523295-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

In 15 ml of conc. sulfuric acid, 3 g of 1,2-dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-3-pyridinecarbonitrile was stirred at 90° C. for 40 minutes. After cooling, the reaction mixture was poured into ice and conc. ammonia water was added thereto to render the mixture alkaline. Crystals prepcipitated were taken by filtration. After washing with water and drying, the crystals were recrystallized from N,N-dimethylformamide to obtain 2.5 g of 1,2-dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-3-pyridinecarboxamide.

後処理

  1. temperatureAfter cooling
  2. additionwas added
  3. filtrationCrystals prepcipitated were taken by filtration
  4. washAfter washing with water
  5. customdrying
  6. customthe crystals were recrystallized from N,N-dimethylformamide

出典と根拠

ORDレコード
ord-675da39d20b347178dc5f484a9c07cb9
出典データセット
uspto-grants-1988_12
特許番号
US04791202

関連ノート

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