Olprinone → 5-(3-Bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromide

HRID 414327ノート

反応式

HRID 414327 の反応式
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([C:10]3[CH:11]=[C:12]([C:18]#[N:19])[C:13](=[O:17])[NH:14][C:15]=3[CH3:16])[CH:7]=[CH:6][C:5]=12.[Br:20]Br>C(O)(=O)C>[BrH:20].[Br:20][C:3]1[N:4]2[CH:9]=[C:8]([C:10]3[CH:11]=[C:12]([C:18]#[N:19])[C:13](=[O:17])[NH:14][C:15]=3[CH3:16])[CH:7]=[CH:6][C:5]2=[N:1][CH:2]=1

参加物

4

反応物 2

HCID 4593OlprinoneHCID 24408Bromine

生成物 1

HCID 212764285-(3-Bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromide収率 155.9%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
30 °C

実験手順

In 10 ml of acetic acid was dissolved 0.3 g of 1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile. To the solution 0.2 g of bromine was added and the mixture was warmed to 30° C. After cooling, precipitated white crystals were taken by filtration. After washing with ether, the crystals were recrystallized from methanol to obtain 0.4 g of 5-(3-bromoimidazo[1,2-a]pyridin-6-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile hydrobromide.

後処理

  1. temperatureAfter cooling
  2. customprecipitated white crystals
  3. filtrationwere taken by filtration
  4. washAfter washing with ether
  5. customthe crystals were recrystallized from methanol

出典と根拠

ORDレコード
ord-cdccdd7ce59947baa674c57fbd21cc1c
出典データセット
uspto-grants-1988_12
特許番号
US04791203

反応ノート

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