Piperidine → Methyl 3-piperidinovalerate

反応式

[C:1]([O:7][CH3:8])(=[O:6])/[CH:2]=[CH:3]/[CH2:4][CH3:5].[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>>[N:9]1([CH:3]([CH2:4][CH3:5])[CH2:2][C:1]([O:7][CH3:8])=[O:6])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

参加物

反応物 2

HCID 8082Piperidine

HCID 5364718Methyl 2-pentenoate

生成物 1

HCID 14178339Methyl 3-piperidinovalerate

反応条件

温度: 65 °C

実験手順

A mixture of 500 g of methyl 2-trans-pentenoate and 372 g of piperidine was heated at 65° C. for 17 hours and then at 100° C. for 24 hours. After distillation over a Vigreux column, 562 g (64% of theory) of methyl 3 -piperidinovalerate of boiling point 64° C./2 mbar, nD20 =1.4592, were obtained.

後処理

distillationAfter distillation over a Vigreux column, 562 g (64% of theory) of methyl 3 -piperidinovalerate of boiling point 64° C./2 mbar
customnD20 =1.4592, were obtained

出典と根拠

ORDレコード: ord-8dd5369b1df347b7a55961ccede03f61
出典データセット: uspto-grants-1988_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04791220

反応ノート

読み込み中…

参加物