Morpholine → Methyl 3-morpholinovalerate

反応式

[C:1]([O:7][CH3:8])(=[O:6])/[CH:2]=[CH:3]/[CH2:4][CH3:5].[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[O:12]1[CH2:13][CH2:14][N:9]([CH:3]([CH2:4][CH3:5])[CH2:2][C:1]([O:7][CH3:8])=[O:6])[CH2:10][CH2:11]1

参加物

反応物 2

HCID 8083Morpholine

HCID 5364718Methyl 2-pentenoate

生成物 1

HCID 20035200Methyl 3-morpholinovalerate

反応条件

温度: 100 °C

実験手順

A mixture of 171 g of methyl 2-trans-pentenoate and 130.5 g of morpholine was heated for 46 hours at 100° C. After distillation of the reaction mixture over a Vigreux column, 179 g (59% of theory) of methyl 3-morpholinovalerate of boiling point 85° C./0.4 mbar, nD20 =1.4610, were obtained.

後処理

distillationAfter distillation of the reaction mixture over a Vigreux column, 179 g (59% of theory) of methyl 3-morpholinovalerate of boiling point 85° C./0.4 mbar
customnD20 =1.4610, were obtained

出典と根拠

ORDレコード: ord-6e72a1f644624095b6631187d859dcda
出典データセット: uspto-grants-1988_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04791220

反応ノート

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