Acetic Anhydride → HCID 19850137、化合物

HRID 414388ノート

反応式

HRID 414388 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH:12][C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([NH:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH:12][C:13](=[O:18])[C:14]([F:15])([F:16])[F:17])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9])(=[O:21])[CH3:20]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 12807541N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

生成物 1

HCID 19850137HCID 19850137、化合物

実験手順

N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoro acetamide (5.24 g., 0.02 moles) in acetic anhydride (20 ml) was boiled at reflux for 2 hr. The anhydride was removed under reduced pressure and the syrupy residue added to water. The grey solid was collected and recrystallised from toluene using charcoal to give the sub-title compound as cream crystals (4.0 g) mp 105°-106°.

後処理

  1. temperatureat reflux for 2 hr
  2. customThe anhydride was removed under reduced pressure
  3. additionthe syrupy residue added to water
  4. customThe grey solid was collected
  5. customrecrystallised from toluene

出典と根拠

ORDレコード
ord-7c4b4a027b10471f8fd3da3a1dd6368f
出典データセット
uspto-grants-1988_12
特許番号
US04791216

反応ノート

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