Aniline → N,N-Di(6-hydroxyhexyl)aniline

HRID 414437

反応式

HRID 414437 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8](=[O:11])([O-])[O-].[K+].[K+].Cl[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21]>>[OH:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][N:1]([CH2:4][CH2:3][CH2:2][CH2:7][CH2:6][CH2:8][OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 6115AnilineHCID 11430Potassium CarbonateHCID 748286-Chloro-1-hexanol

生成物 1

HCID 21982671N,N-Di(6-hydroxyhexyl)aniline収率 127%

実験手順

A mixture of freshly distilled aniline (93 g, 1.10 mol), potassium carbonate (304 g, 2.2 mol), 6-chloro-1-hexanol (300.0 g, 2.2 mol), and 500 mL of η-butanol was heated at reflux for 82 hours under nitrogen with vigorous stirring. After cooling and filtering, the butanol was evaporated at reduced pressure to leave a tan oil. The oil was fractionally distilled in vacuo, yielding 205 g (70%) of the title compound as a colorless oil, bp 195°-225° C. (0.15 nm).

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 82 hours under nitrogen with vigorous stirring
  3. temperatureAfter cooling
  4. filtrationfiltering
  5. customthe butanol was evaporated at reduced pressure
  6. customto leave a tan oil
  7. distillationThe oil was fractionally distilled in vacuo

出典と根拠

ORDレコード
ord-f6dca47b9d6843ab8a95e443433ac928
出典データセット
uspto-grants-1988_12
特許番号
US04792208

関連ノート

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