Nicotinic Acid → Norfloxacin nicotinate

HRID 414447

反応式

HRID 414447 の反応式
[CH3:1][CH2:2][N:3]1[C:9]2[CH:10]=[C:11]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]([F:14])=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:21]([OH:23])=[O:22])=[CH:4]1.C(O)(=O)C1C=CC=NC=1>C(O)C>[C:21]([OH:23])(=[O:22])[C:5]1[CH:6]=[CH:8][CH:9]=[N:3][CH:4]=1.[CH3:1][CH2:2][N:3]1[C:9]2[CH:10]=[C:11]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]([F:14])=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:21]([OH:23])=[O:22])=[CH:4]1

参加物

4

反応物 2

HCID 938Nicotinic AcidHCID 4539Norfloxacin

生成物 1

HCID 83908Norfloxacin nicotinate収率 88%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

10 g of Norfloxacin were added to 20 ml of ethanol, the mixture obtained was then stirred and heated to reflux. 4.2 g of nicotinic acid, previously dissolved in 5 ml of hot ethanol, were added in one portion to said mixture and the resulting suspension was heated to reflux, upon which all solids dissolved. After a short time at reflux the adduct began to separate. The mixture was stirred, cooled to room temperature and finally in an ice bath to yield the nicotinic acid-Norfloxacin 1:1 adduct in 88% yield; m.p. 232°-233° C.

後処理

  1. customthe mixture obtained
  2. temperatureheated to reflux
  3. additionwere added in one portion
  4. temperaturethe resulting suspension was heated
  5. temperatureto reflux, upon which all solids
  6. dissolutiondissolved
  7. temperatureAfter a short time at reflux the adduct
  8. customto separate
  9. stirringThe mixture was stirred

出典と根拠

ORDレコード
ord-d1c114c294724bda82cd49333e3ac512
出典データセット
uspto-grants-1988_12
特許番号
US04792552

関連ノート

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