関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl 4-fluorobenzoate | HCID 67878 | — |
| 反応物 | 1-Chloro-1-fluoro-4-carbomethoxy-cyclohexane | HCID 14365662 | — |
| 反応物 | 1-Chloro-4-carbomethoxy cyclohexane | HCID 21281591 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 生成物 | Methyl cis-4-fluorocyclohexanecarboxylate | HCID 21281592 | 85% |
反応手順
A mixture of 1.2 parts of 1-chloro-1-fluoro-4-carbomethoxy-cyclohexane and 4.8 parts of o-dichlorobenzene were added to a bed of 2% palladium on carbon maintained at 300° C. A stream of nitrogen at 400 cc/min. swept the products into two cold traps at 0° C. and -80° C. to yield 3.84 parts of combined products. Analysis by gas chromatography and mass spectrometry indicated complete reaction to yield 85% 1-fluoro-4-carbomethoxy-cyclohexane, 5% 1-chloro-4-carbomethoxy-cyclohexane and 10% methyl-4-fluorobenzoate, excluding the solvent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04792618 |
|---|
| 出典データセット | uspto-grants-1988_12 |
|---|
| ORD ID | ord-0ce02448cff94ef2b6e7e893ec8ecb9d |
|---|
| 出典メモ | uspto-grants-1988_12 |
|---|
