1-Diethoxyphosphorylethanol → Diethyl 1-[2-[5-(o-chloro-p-trifluoromethyl-phenoxy)-2-nitrophenoxy]-propionyloxy]-ethylphosphonate

反応式

[Cl:1][C:2]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:17]([O-:19])=[O:18])=[C:9]([CH:16]=1)[O:10][CH:11]([CH3:15])[C:12](Cl)=[O:13].[OH:28][CH:29]([P:31](=[O:38])([O:35][CH2:36][CH3:37])[O:32][CH2:33][CH3:34])[CH3:30]>>[Cl:1][C:2]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:17]([O-:19])=[O:18])=[C:9]([CH:16]=1)[O:10][CH:11]([CH3:15])[C:12]([O:28][CH:29]([P:31](=[O:38])([O:32][CH2:33][CH3:34])[O:35][CH2:36][CH3:37])[CH3:30])=[O:13]

参加物

反応物 2

HCID 5191091-Diethoxyphosphorylethanol

HCID 131006842-[2-Nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenoxy]propionyl Chloride

生成物 1

HCID 21281541Diethyl 1-[2-[5-(o-chloro-p-trifluoromethyl-phenoxy)-2-nitrophenoxy]-propionyloxy]-ethylphosphonate

実験手順

by using 2-[5-(o-chloro-p-trifluoromethyl-phenoxy)-2-nitrophenoxy]-propionyl chloride and diethyl 1-hydroxyethylphosphonate there is obtained diethyl 1-[2-[5-(o-chloro-p-trifluoromethyl-phenoxy)-2-nitrophenoxy]-propionyloxy]-ethylphosphonate, 1H-NMR (CDCl3, 400 MHz) 7.93 ppm and 7.92 ppm (2d, 1H), 7.79 ppm (d, 1H), 7.51-7.55 ppm (m, 1H), 7.23 ppm and 7.19 ppm (2d, 1H), 6.68 ppm and 6.58 ppm (2d, 1H), 6.53 ppm and 6.46 ppm (2q, 1H), 5.31 ppm and 5.29 ppm (2q, 1H), 4.88 and 4.85 ppm (2q, 1H), 4.21-4.05 ppm (m, 4H), 1.73 ppm and 1.72 ppm (2d, 3H), 1.45 ppm and 1.42 ppm (2q, 3H), 1.36-1.26 ppm (m, 6H).

出典と根拠

ORDレコード: ord-859c9108d6424732b492ee1f2f21015d
出典データセット: uspto-grants-1988_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04792616

反応ノート

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