化工社化工社 化学情報印刷レポート · 研究参考用
N-Methylol-alpha-chloroacetamide → 4-Methyl-6-alpha-chloroacetylaminomethyl-7-hydroxy-1-indanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylol-alpha-chloroacetamide | HCID 62466 | — |
| 反応物 | 7-Hydroxy-4-methyl-1-indanone | HCID 12436244 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 4-Methyl-6-alpha-chloroacetylaminomethyl-7-hydroxy-1-indanone | HCID 13604141 | — |
反応手順
9.3 Grams of 4-methyl-7-hydroxy-1-indanone and 30 g of N-hydroxymethyl-α-chloroacetamide were dissolved by adding 280 ml of concentrated sulfuric acid under a cooling condition. After the mixture was allowed to stand overnight, the mixture was poured into ice-water. The crystals formed in the mixture were collected by filtration and were recrystallized from ethanol to obtain 49 g of 4-methyl-6-α-chloroacetylaminomethyl-7-hydroxy-1-indanone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04792628 |
| 出典データセット | uspto-grants-1988_12 |
| ORD ID | ord-4a7e1f9656b248dd9a61a3d930cddd9f |
| 出典メモ | uspto-grants-1988_12 |