Sulfuric Acid → 4-Methyl-6-aminomethyl-7-hydroxy-1-indanone

HRID 414677ノート

反応式

HRID 414677 の反応式
[CH3:1][C:2]1[CH:10]=[C:9]([CH2:11][NH:12]C(=O)CCl)[C:8]([OH:17])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:18].S(=O)(=O)(O)O>C(O)C>[CH3:1][C:2]1[CH:10]=[C:9]([CH2:11][NH2:12])[C:8]([OH:17])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:18]

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 136041414-Methyl-6-alpha-chloroacetylaminomethyl-7-hydroxy-1-indanone

生成物 1

HCID 136041444-Methyl-6-aminomethyl-7-hydroxy-1-indanone

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3 Grams of 4-methyl-6-α-chloroacetylaminomethyl-7-hydroxy-1-indanone and a solution of 30 ml of concentrated sulfuric acid in 60 ml of ethanol were refluxed by heating for 8 hours. The solvent was removed by evaporation, the residue thus obtained was recrystallized from ethanol to obtain 1 g of 4-methyl-6-aminomethyl-7-hydroxy-1-indanone.

後処理

  1. temperatureby heating for 8 hours
  2. customThe solvent was removed by evaporation
  3. customthe residue thus obtained
  4. customwas recrystallized from ethanol

出典と根拠

ORDレコード
ord-d178894b4e4c4482b7509e98b99d4b09
出典データセット
uspto-grants-1988_12
特許番号
US04792628

反応ノート

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