Acetic Acid → 4-Methyl-6-acetamido-7-hydroxy-1-indanone

HRID 414678

反応式

HRID 414678 の反応式
[CH3:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([OH:14])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:15].[C:16](O)(=[O:18])[CH3:17]>[C].[Pd]>[CH3:1][C:2]1[CH:10]=[C:9]([NH:11][C:16](=[O:18])[CH3:17])[C:8]([OH:14])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:15]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 136041424-Methyl-6-nitro-7-hydroxy-1-indanone

生成物 1

HCID 136041464-Methyl-6-acetamido-7-hydroxy-1-indanone

試薬・触媒・溶媒 1

HCID 178418390HCID 178418390、化合物触媒

実験手順

Into a solution of 11.5 g of 4-methyl-6-nitro-7-hydroxy-1-indanone in 500 ml of acetic acid was added 1.5 g of 5% palladium carbon, then the mixture was subjected to a catalytic hydrogenation under an atmospheric pressure at a room temperature. The catalyst was removed by filtration and the solvent was removed by evaporation. The residue obtained was washed with ether and was recrystallized from methanol to obtain 6.34 g of 4-methyl-6-acetamido-7-hydroxy-1-indanone.

後処理

  1. customwas subjected to a catalytic hydrogenation under an atmospheric pressure at a room temperature
  2. customThe catalyst was removed by filtration
  3. customthe solvent was removed by evaporation
  4. customThe residue obtained
  5. washwas washed with ether
  6. customwas recrystallized from methanol

出典と根拠

ORDレコード
ord-acbcc05080a54311b75436cdf25ec350
出典データセット
uspto-grants-1988_12
特許番号
US04792628

関連ノート

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