Hydrochloric Acid → 1-Amino-7-hydroxy-4-methylindane hydrochloride

HRID 414687

反応式

HRID 414687 の反応式
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:13])=[C:6]2[C:10]=1[C:9](=[N:11]O)[CH2:8][CH2:7]2.[H][H].[ClH:16]>C(O)(=O)C.[Pt]=O.C(O)C>[ClH:16].[NH2:11][CH:9]1[C:10]2[C:6](=[C:5]([CH3:13])[CH:4]=[CH:3][C:2]=2[OH:1])[CH2:7][CH2:8]1

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 1363428377-Hydroxy-4-methyl-1-indanone oximeHCID 178418361HCID 178418361、化合物

生成物 1

HCID 136041701-Amino-7-hydroxy-4-methylindane hydrochloride

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 176Acetic Acid溶媒HCID 702Ethanol溶媒

実験手順

15.0 Grams of 7-hydroxy-4-methyl-1-indanone oxime was dissolved in 200 ml of acetic acid, then 1.0 g of platinum oxide catalyst was added thereto and the mixture was subjected to catalytic reduction under 5 atmospheric pressure of hydrogen gas at a room temperature for 8 hours. The catalyst was removed by filtration, then the filtrate was concentrated to dryness under a reduced pressure. The residue thus obtained was dissolved in 200 ml of ethanol and hydrogen chloride gas was blown into the solution to become saturated. The solvent was removed by evaporation under a reduced pressure, the residue was recrystallized from ethanol to obtain 3.30 g of 1-amino-7-hydroxy-4-methylindane hydrochloride in the form of colorless needle-like crystals. Melting point: 221°-223° C.

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated to dryness under a reduced pressure
  3. customThe residue thus obtained
  4. customThe solvent was removed by evaporation under a reduced pressure
  5. customthe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-f6655bee8571400c83811f3302bde56e
出典データセット
uspto-grants-1988_12
特許番号
US04792628

関連ノート

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