2-Chlorobenzylamine → 2-(2-Chloro-benzylamino)-6H-pyrido[4,3-d]pyrimidin-5-one
反応式
CS[C:3]1[N:4]=[CH:5][C:6]2[C:12](=[O:13])[NH:11][CH:10]=[CH:9][C:7]=2[N:8]=1.[Cl:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17][NH2:18]>CO.O>[Cl:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17][NH:18][C:3]1[N:4]=[CH:5][C:6]2[C:12](=[O:13])[NH:11][CH:10]=[CH:9][C:7]=2[N:8]=1参加物
4
実験手順
2-Methylsulfanyl-6H-pyrido[4,3-d]pyrimidin-5-one 6 (3.00 g, 15.5 mmol) and 2-Chlorobenzyl amine 7 (9.40 mL, 77.6 mmol) were stirred at 150° C. for two days. To the recooled mixture Methanol/water (1:1, 100 mL) was added and left at RT overnight. The precipitate was filtered off and dried in vacuo. The product was purified by crystallization from ethanol to yield in a colorless solid (4.00 g, 14.0 mmol, 90%).
後処理
- filtrationThe precipitate was filtered off
- customdried in vacuo
- customThe product was purified by crystallization from ethanol
出典と根拠
- ORDレコード
- ord-a539f3bbb8ab425cbaeb4efe79c586f2
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530650B2
反応ノート
読み込み中…